Polynucleotides: The Ultimate Skin Booster & Regeneration Treatment Explained

If you’ve seen the word polynucleotides everywhere lately but aren’t quite sure what they are: you’re not alone. Over the past year, this treatment has become one of the most searched-for skin rejuvenation options in the UK, especially for clients looking for safe, natural, regenerative skin boosters.

At NovaLx, we hear the same questions every day:

• Are polynucleotides better than Profhilo?

• Should I choose this instead of Laser Genesis?

• Is it safer than microneedling, PRP or CO₂ laser?

  
  

This guide explains everything clearly; what polynucleotides are, how they work, who they’re suitable for, and how they compare to other popular treatments.

What Are Polynucleotides?

Polynucleotides are naturally occurring molecules derived from DNA. When injected into the skin, they act as biostimulators, encouraging the skin to repair, regenerate and rejuvenate itself from within.

Unlike fillers or heat-based treatments, polynucleotides are focused on skin health, not volume or tightening.

How polynucleotide injections work:

✔ Stimulate collagen and elastin

✔ Increase skin hydration

✔ Strengthen thin or fragile skin

✔ Improve elasticity and firmness

✔ Reduce crepey texture

✔ Soothe inflammation and support healing

Think of polynucleotides as a reset button for tired, ageing or compromised skin.

What Results Can I Expect?

Most people notice:

✔ Softer, smoother skin

✔ Improved elasticity

✔ Better hydration

✔ A healthier, “lit-from-within” glow

✔ Reduced crepiness (especially under the eyes, neck and hands)

Results build because this is a regenerative treatment: not a filler and not a heat-based procedure. Most clients see their best results after 2–3 sessions.

Are Polynucleotides Safe as a Skin Booster Treatment?

Yes. Polynucleotides have been used medically for decades, especially for wound healing. In aesthetics, research shows a very strong safety profile.

Possible temporary side effects include:

• Mild redness

• Small raised bumps at injection points

• Light swelling or bruising

  
  

These typically settle within 24–48 hours.

Overall, they're considered one of the safest injectable treatments available, especially for clients with sensitive or reactive skin.

Polynucleotides vs Other Skin Treatments

Below is a clear, easy-to-understand comparison between polynucleotides and other popular rejuvenation treatments at NovaLx.

Polynucleotides vs Laser Genesis

Laser Genesis uses gentle, non-invasive heat to improve redness, pores and overall radiance.

Choose Laser Genesis for:

✔ Redness/Rosacea

✔ Enlarged pores

✔ Dull skin

✔ Superficial texture

Choose Polynucleotides for:

✔ Crepey texture

✔ Loss of elasticity

✔ Fine lines

✔ Dehydration

Best option?

Many clients combine both:

Laser Genesis = surface clarity

Polynucleotides = deep skin regeneration

Polynucleotides vs RF Microneedling

RF Microneedling uses tiny needles and radiofrequency heat to repair deeper lines, scars and laxity.

RF Microneedling is best for:

✔ Acne scarring

✔ Stretch marks

✔ Skin tightening

✔ More severe texture issues

Polynucleotides are best for:

✔ Gentle rejuvenation

✔ Strengthening thin skin

✔ Improving elasticity

✔ Supporting recovery

Best option?

Choose Polynucleotides for skin strengthening without heat..

Choose RF Microneedling for more dramatic tightening and scar repair.

Polynucleotides vs Microneedling

Both stimulate collagen - but differently.

Microneedling:

Uses micro-injury to rebuild texture.Best for fine lines, uneven texture, mild scarring.

Polynucleotides:

Regenerate and hydrate.Best for thin, crepey, delicate or dehydrated skin.

Best option?

Texture concerns → microneedling

Elasticity + hydration → polynucleotides

Many clients alternate both for a combined effect.

Polynucleotides vs PRP (Platelet-Rich Plasma)

Both are regenerative treatments.

PRP:

✔ Uses your own blood

✔ Results vary based on your biology

✔ Great for natural healing

Polynucleotides:

✔ More consistent

✔ No blood draw

✔ Powerful for hydration + elasticity

Best option?

Choose PRP if you prefer fully natural, autologous treatment.

Choose polynucleotides for predictable, proven regeneration.

Polynucleotides vs Profhilo

One of the most common comparisons.

Profhilo:

✔ Pure hyaluronic acid

✔ Fast hydration and glow

✔ Quick results

Polynucleotides:

✔ Regenerate and strengthen the skin

✔ Improve elasticity

✔ Work gradually with longer-lasting results

Best option?

Hydration + glow → Profhilo

Elasticity + regeneration → Polynucleotides

Many clients alternate both treatments.

Polynucleotides vs Fractional CO₂ Laser

Fractional CO₂ laser is one of the most advanced resurfacing treatments.

CO₂ Laser is best for:

✔ Deep wrinkles

✔ Sun damage

✔ Scarring

✔ Strong resurfacing (But it includes downtime.)

Polynucleotides are best for:

✔ Gentle rejuvenation

✔ Elasticity

✔ Prevention

✔ Minimal downtime

For dramatic results → CO₂ laser

For natural skin regeneration → Polynucleotides

Learn more about CO₂ fractional laser resurfacing➡️ Understanding Fractional CO2 Laser Resurfacing for Healthy, Youthful Skin

Who Is the Best Candidate for Polynucleotides?

This treatment is ideal if you want:

✔ Firmer, healthier skin

✔ Improvement of crepiness

✔ A naturally rejuvenated appearance

✔ Minimal downtime

✔ Safe treatment for thin or sensitive skin

Suitable for most skin types, including rosacea-prone and sensitised skin.

How Many Sessions Do I Need?

Most clients achieve optimal results with:

• 2–3 sessions

• 2–4 weeks apart

• With maintenance 1–2 times a year

  
  

The improvements continue to build as your skin regenerates.

Summary: Why Polynucleotides Are So Popular?

Because they:

• Improve the foundation of the skin

• Boost natural collagen and elastin

• Strengthen thin or crepey skin

• Deliver subtle, refined, natural-looking results

• Pair beautifully with other treatments

• Offer long-lasting rejuvenations

  
  

Ready to Start Your Skin Regeneration Journey?

If you’re considering polynucleotide skin boosters, or you’re unsure whether polynucleotides or another treatment suits your goals, the NovaLx team will guide you professionally and gently.

Your skin deserves personalised care — and we’re here to help you achieve lasting radiance.

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